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Assessing Carcinogenicity: Hazard Identification, Classification, and Risk Assessment.  A Toxicology Forum State-of-the-Science Workshop


December 7–10, 2020 | Held as a Virtual Workshop


This virtual workshop is planned as two parts.

Scientific Program: Registrants will have access to view recorded speaker presentations beginning one month in advance of the virtual workshop, allowing ample time for registrants to become familiar with the diverse subject matter.

In addition to the recorded scientific presentations, a Virtual Poster Session will be available to all attendees beginning in November. Workshop attendees may submit an abstract(s) for inclusion as a poster or other similar presentation medium that is hosted as part of the Virtual Poster Session—increasing the dialogue, knowledge-sharing, and networking opportunities available to all attendees.

Live Dialogue and Knowledge-Sharing: During the scheduled dates of the virtual workshop, attendees will have the opportunity to ask questions and participate in the panel and group discussions pertaining to the day's subject matter. To accommodate attendees from across the world, the live virtual workshop will last 3-hours per day.


How will the live virtual workshop function? Dialogue among presenters and attendees is a pillar of Toxicology Forum Meetings. During the live virtual workshop, attendees will be able to contribute to the live discussion(s), ask questions, share their views, and collaborate throughout the sessions.

Your voice and viewpoints drive the dialogue and we look forward to your continued contributions!



Workshop Details


As our understanding of chemical carcinogenesis has grown significantly over the last several decades, it is appropriate to look at whether long-standing test methods and risk assessment approaches should be updated based on new understandings.  The US EPA is now in the process of updating its guidelines for risk assessment, which includes the 2005 Guidelines for Carcinogen Risk Assessment. These guidelines are used throughout the US EPA, as well as by numerous other federal and state agencies, to aid regulatory decision-making and set research priorities. This workshop will provide an opportunity for national/international experts and stakeholders to engage in an information exchange regarding these revisions, which will be of great value to guide next steps towards the modernization of carcinogenicity identification and risk assessment.

The US EPA Administrator has challenged EPA to significantly reduce the use of animal toxicity testing.  This coincides with new directions being taken by the NTP to eventually move away from the chronic rodent bioassay toward human-relevant testing methods that significantly reduce or move away from animal testing altogether.  Also, others are involved in the development of non-animal methods that are being proposed for use in cancer risk assessment and human-relevant chemical carcinogens identification, including toxicogenomics, cell transformation assays, high-throughput screening assays (e.g., ToxCast) used to identify “Key Characteristics of Carcinogens”, as well as weight of evidence assessments ongoing for pharmaceuticals (ICH S1 update) and agrochemicals (US EPA ReCAAP project).  Although these newer methods are still in development, they are already starting to be used by some regulatory agencies, increasing the need for an information exchange on how these tests should be conducted and how data should be interpreted.  It is of value to reflect international experience because of the efficiencies resulting from achieving harmonized guidance across geographies to the greatest extent possible.

This virtual workshop is dedicated to presentations and discussions on “Carcinogenicity problem formulation”, “dose-response assessment”, “Mode-of-action state-of-the-science” and “New approach methodologies.” 

Throughout the virtual workshop presenters and attendees will be able to gain greater insight and understanding around the following key challenges:

  • Is there new science that better informs how we determine if a chemical causes an increased risk of cancer at relevant doses or contributes to an increased risk of cancer in the presence of other chemicals or stressors?
  • Is there new understanding about key events, key characteristics, and AOPs that informs this question?
  • Are there new kinds of data that better inform judgments about human relevance or dose-response?
  • Is there new science that establishes adverse outcome pathways to cancer in a chemical-agnostic and quantitative form?
  • Is there new data or new science that informs how to extrapolate from observed responses to responses at “acceptable” or “de minimis” risk levels?
  • Is there new data or new science that better informs understanding of population variability in response?

Workshop Co-Chairs: Susan Felter, Procter & Gamble Company; and Edward Ohanian US EPA

Planning Committee:

Virunya Bhat, ToxStrategies Inc.
Phil Botham, Syngenta
David Bussard, US EPA
Warren Casey, NIEHS/NTP
Suzanne Fitzpatrick, US FDA/CFSAN
Wally Hayes, University of South Florida
Gina Hilton, PETA International Science Consortium
Kelly Magurany, NSF International

The virtual workshop is split into two parts. 

All speaker presentations will be recorded in advance. The complete agenda of speakers and presentation information can be accessed on the Scientific Program webpage.

  View the Scientific Program

The live portion of the virtual workshop will occur December 7–10, 2020. Each day will dedicate three hours of time for attendee questions, discussion, and collaboration among participants. Each day will be dedicated to a specific session. The schedule for each day of the virtual workshop can be accessed on the Workshop Schedule webpage.

  View the Workshop Schedule

Workshop attendees are welcome and encouraged to submit an abstract for inclusion as a poster or similar presentation medium as part of a Virtual Poster Session that is available for all attendees.

All submissions within the topic-area and scope of this workshop are welcome.

Abstract Submission Deadline: October 30, 2020

  Submit Your Abstract

Workshop attendees will be able to view accepted abstracts, further enriching their learning opportunities and providing an opportunity for everyone to share their latest research and findings.

There is no fee to submit your abstract for consideration.

Please contact The Toxicology Forum with any questions or concerns about the Virtual Poster Session.


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Please be sure to register by November 8 so that you will have the opportunity to view the recorded presentations in a timely manner.


  Click Here to Register


Registration Fees:

Member $150 
Nonmember (Academia/Government/Non-profit) $225 
Nonmember (Industry) $300


The workshop will have two distinct parts in order to best facilitate discussion knowledge sharing among participants.

All speaker presentations (which typically take-up a large portion of meeting time) will be recorded in advance. All registrants will have approximately one-month to view the presentations at their leisure to expand their knowledge-base about the topic and prepare for the live workshop discussions. The scientific program is divided into 4 sessions.

The live portion of the workshop will occur December 7–10, 2020. Each day will dedicate three hours of time for attendee questions, discussion, and collaboration among participants. Each day will be dedicated to a specific session. 

Questions: Please contact Kevin Merritt at The Toxicology Forum, either via email or phone {1.703.547.0876} with any questions or concerns about the workshop.